Inna P. Gladysheva, PhD

Inna P. Gladysheva, PhD portrait
    • Primary Address
    • Office
    • University of Arizona College of Medicine - Phoenix
    • Biomedical Sciences Partnership Building
    • 475 North 5th Street, E820
    • Phoenix, AZ, United States 85004


Research Statement

Lab. translational research is focused on the molecular and pathophysiologic mechanisms of cardiomyopathy, heart failure and concurrent complications. Major long-term goal of the lab. translational research is to delay or prevent transition from pre-symptomatic (cardiomyopathy) to symptomatic heart failure characterized by fluid retention (edema) and progressive muscle wasting (cachexia/sarcopenia). Little is known about the predictors (biomarkers) and effectors (bio-targets) for this transition. The difficulty of objectively detecting and reproducible quantify edema and muscle mass is one of the major challenges in heart failure management. Toward this major goal we are interested in: •Biomarkers/bio-targets defining transition from heart dysfunction to heart failure; •Mechanisms responsible for alteration of biological pathways associated with transition; •Preventive potential of dietary, pharmacologic & genetic interventions; •Impact and potential of lifestyle choices; •Sex-related alteration of this transition; •Noninvasive objective technologies for edema and cachexia/sarcopenia monitoring; •Precise consideration of the individual’s biomarker profile and sex. Research combines animal, biochemical and cell culture approaches, and clinical research.

Area of Expertise

  • Heart Failure (Research)
  • Cardiomyopathy (Research)

Research Summary

Research is focused on the molecular and pathophysiologic mechanisms of cardiomyopathy, heart failure, and concurrent complications in order to delay or prevent the transition from cardiac dysfunction (cardiomyopathy) to symptomatic heart failure characterized by edema and cachexia/sarcopenia. Specifically, we are interested in proteases and hormones as potential diagnostic and therapeutic targets and pharmacological and other approaches (lifestyle choices) to slow progression to heart failure.

List of Published Work