Inna P. Gladysheva, PhD

Inna P. Gladysheva, PhD portrait
    • Primary Address
    • Business
    • Biomedical Sciences Partnership Building
    • 475 North 5th Street
    • Phoenix, AZ, United States 85004

Research

Research Summary

The molecular and pathophysiologic mechanisms of cardiomyopathy, heart failure and concurrent complications

Research/Scholarship Projects

  • Corin in Cardiomyopathy and Heart Failure. PI: Gladysheva I.P. R01HL115036. 08/2012 - 06/2018.

Research Statement

Lab. translational research is focused on the molecular and pathophysiologic mechanisms of cardiomyopathy, heart failure and concurrent complications. Specifically, we are interested in proteases and hormones as potential diagnostic and therapeutic targets for cardiovascular diseases, in modulating progression of cardiomyopathy and heart failure. Research combines animal, biochemical and cell culture approaches, and clinical research. Major long-term goal of the lab. translational research is to delay or prevent transition from pre-symptomatic (cardiomyopathy) to symptomatic heart failure characterized by fluid retention (edema) and progressive muscle wasting (cachexia/sarcopenia). Still, little is known about the predictors (biomarkers) and effectors (bio-targets) for this transition. The difficulty of objectively detecting and reproducible quantify edema and muscle mass is one of the major challenges in heart failure management. Toward this major goal we are interested in: • Biomarkers/bio-targets defining transition • Mechanisms responsible for alteration of biological pathways associated with transition • Preventive potential of dietary, pharmacologic & genetic interventions and impact of lifestyle • Sex-related alteration of this transition • Noninvasive objective technologies for edema and cachexia/sarcopenia monitoring • Precise consideration of the individual’s biomarker profile and sex.