Inna P. Gladysheva, PhD

Inna P. Gladysheva, PhD portrait
    • Primary Address
    • Business
    • Biomedical Sciences Partnership Building
    • 475 North 5th Street
    • Phoenix, AZ, United States 85004

Research

Research Summary

The molecular and pathophysiologic mechanisms of cardiomyopathy, heart failure and concurrent complications

Research/Scholarship Projects

  • Corin in Cardiomyopathy and Heart Failure. PI: Gladysheva I.P. R01HL115036. 08/2012 - 06/2018.

Research Statement

Lab. translational research is focused on the molecular and pathophysiologic mechanisms of cardiomyopathy, heart failure and concurrent complications. Specifically, we are interesting in proteases and hormones as potential diagnostic and therapeutic targets for cardiovascular diseases, in particular in modulating progression of cardiomyopathy and heart failure. Research combines animal, biochemical and cell culture approaches, and clinical research. Major long-term goal of the lab. translational research is to delay or prevent transition from pre-symptomatic (cardiomyopathy) to symptomatic heart failure. Still, little is known about the predictors (biomarkers) and effectors (bio-targets) for this transition. Toward this major goal we are interesting in: • Biomarkers/bio-targets defining transition • Mechanisms responsible for alteration of biological pathways associated with transition • Preventive potential of dietary, pharmacologic & genetic interventions and impact of lifestyle • Sex-related alteration of this transition • Precise consideration of the individual’s biomarker profile and sex